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Clofi 50 contains
an active ingredient called Clomiphene Citrate. It is generally administered by
oral route, it is available in tablet Form. Clofi 50 mg is used for
treating female infertility and for certain conditions as determined by your
doctor. Clofi 50 mg is an ovulatory stimulant. It works by helping to produce
more hormones that cause your ovaries to release.
What is this
medicine?
Clomiphene
is a fertility drug used to increase the chance of getting pregnant. It is used
to help women ovulate (produce a mature egg) properly during their cycle.
Compared to other fertility treatments, clomiphene alone does not greatly
increase your chances of having multiple babies. An increased chance of having
twins may occur in roughly 5 out of every 50 women who take this medication.
Occasionally clomiphene is prescribed to men with fertility problems due to low
sperm counts.
How Clofi 50
mg used and works?
To
understand why and how clomiphene is used, it is important to have a basic
understanding of normal ovulation. Normally, a woman’s ovaries produce one egg
every 24 to 35 days. Ovulation usually occurs about 12 to 14 days before the
next menstrual period. A woman’s best chance for becoming pregnant occurs
around the day of ovulation and one to two days before ovulation. This would be
approximately 12 to 14 days after the first day of a 28-day menstrual cycle.
Women who
are most likely to respond to clomiphene include those with polycystic ovary
syndrome. Women who are unlikely to respond are those with absent periods and
very low estrogen levels due to low body weight or exercise, or those with high
follicle-stimulating hormone levels, an indicator of ovarian aging early
menopause or primary ovarian insufficiency.
Clofi 50 mg
works at the level of the hypothalamus where it competes for estrogen binding
places. When these places are occupied by Clofi 50 mg, the hypothalamus
responds by producing more gonadotropin releasing hormone, which then
stimulates the pituitary to produce follicle-stimulating hormone.
In a normal
cycle healthy follicles produce estrogen, which signals the hypothalamus to
reduce production of follicle-stimulating hormone. Women must monitoring their
follicular development via ultrasound and blood tests to measure estradiol.
Dosage and
direction
Clofi 50 mg
is administered to stimulate ovulation 50 mg 1 time a day at bedtime, starting
from 5th day of the menstrual cycle during 5 days (in the absence of the cycle
– at any time). In case of no effect (ovulation does not occur within 30 days)
increase the dose to 150 mg / day or lengthen the course to 10 days. Take
exactly as prescribed, do not take the medication in larger quantities.
How should I
take this medicine?
Take this
medicine by mouth with a glass of water. Take exactly as directed for the exact
number of days prescribed. Take your doses at regular intervals. Most women
take this medicine for a 5 day period, but the length of treatment may be
adjusted. Your doctor will give you a start date for this medication and will
give you instructions on proper use. Do not take your medicine more often than
directed.
Talk to your
pediatrician regarding the use of this medicine in children. Special care may
be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This
medicine is only for you. Do not share this medicine with others.
Precautions
Before to
take Clofi 50 mg notify your doctor if you have ever had any allergic reaction
to clomiphene, liver diseases, mental depression, thrombophlebitis. This drug
may cause vision problems, dizziness, or lightheadedness, be especially
attentive if you need driving or operating machinery which requires high
concentration of attention.
Contraindications
Hypersensitivity,
liver or kidney failure, metrorrhagia of unknown etiology, ovarian cysts,
neoplasms of genital organs, tumor or hypofunction of the hypophysis,
endometriosis, ovarian failure together with hyperprolactinaemia, pregnancy.
Possible side
effect
Together
with allergy symptoms such as swelling of lips, tongue, or face or hives in
some patients may appear the following conditions: ovarian enlargement
presenting as abdominal or pelvic pain, flushing, nausea, vomiting, or
diarrhea, blurred vision, headache, abnormal uterine bleeding.
Drug
interaction
Inform your
doctor and laboratory operators about all medications and herbal products you
are taking if you are treated with Clofi 50mg.
Missed dose
If you
missed a dose take it as soon as you remember, but not if it is almost time of
the next intake by your schedule. If so skip the missed dose. Do not try to
make up a missed dose by taking an extra one.
Overdose
If you
suspect that you took too much of the medication seek for immediate medical
attention.
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